Lincomycin Administration against Persistent Multi-Drug Resistant Chronic Endometritis in Infertile Women with a History of Repeated Implantation Failure

Chronic endometritis (CE) is an infectious disease of the uterine lining, which characterized by endometrial stromal plasmacyte (ESPC) infiltration. CE often seen in infertile women with a history repeated implantation failure (RIF) following vitro fertilization-embryo transfer program, recurrent pregnancy loss, and unknown etiology. Oral antibiotic agents, such as doxycycline, metronidazole, ciprofloxacin, azithromycin, moxifloxacin, have been prescribed are effective treatment CE. Multi-drug resistance (MDR), however, emerging issue, other medical fields. We report six cases persistent MDR-CE who were resistant to all aforementioned agents. The bacterial genera microbial communities unique not identified their vaginal secretions and/or fluid. lincomycin administration (14 days, 1500 mg/day) was eradication ESPCs these women. In embryo cycles histopathologic confirmation cure (elimination ESPCs) MDR-CE, three out them had successful live birth.